Yeghishe Ishkhanian (Armenian: ????? ?????????; January 1, 1886, Shusha – April 28, 1975) was a prominent Armenian politician and statesman, who held high offices in the Nagorno-Karabakh in the beginning of the 20th century.
From July 27, 1918 to February 20, 1919, Ishkhanian headed the People's Government of Karabakh (subsequently renamed the Karabakh Council).
Subsequently he was elected to be vice-president of the National Council.