Zeno Karcz (born May 16, 1935) is a former linebacker in the Canadian Football League.
Having played his junior football with the Windsor AKO Fratmen, he went on to the Hamilton Tiger-Cats (from 1957 to 1966) in the CFL.
He was an all star in 1962 and 1965, winning the CFL's Most Outstanding Canadian Award in 1965.
He was a member of the 1957, 1963 and 1965 Grey Cup championship teams.
After retiring from professional football, he returned to the Windsor AKO Fratmen as head coach between 1967 and 1969.