Arthur Biedl, Date of Birth, Place of Birth, Date of Death

    

Arthur Biedl

Hungarian pathologist

Date of Birth: 04-Oct-1869

Place of Birth: Comloșu Mic, Timiș County, Romania

Date of Death: 26-Aug-1933

Profession: professor, physiologist, pathologist, endocrinologist

Nationality: Austria

Zodiac Sign: Libra


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About Arthur Biedl

  • Arthur Biedl (4 October 1869 – 26 August 1933) was a Hungarian pathologist born in what today is Comlosu Mic, Romania. He studied medicine at the University of Vienna, and from 1893 served as an assistant to Salomon Stricker (1834-1898), Philipp Knoll (1841-1900) and Richard Paltauf (1858-1924) at the institute of experimental pathology in Vienna.
  • In 1899 he became an associate professor, followed by a full professorship in 1902. In 1898, Biedl and colleague R.
  • Kraus demonstrated that "bile salts," when injected into the bloodstream of animals, failed to elicit a behavioral change.
  • They hypothesized that this was due to a semipermeable membrane that protected the central nervous system from the passive diffusion of solutes in the bloodstream.
  • Two years later, Max Lewandowsky coined the term "Blood–brain barrier" when these findings were confirmed with other biological compounds.
  • Edwin Goldmann and his mentor Paul Ehrlich further confirmed these findings with aniline dyes injected inside and outside of the brain.He is considered a founder of modern endocrinology.
  • In 1910, Biedl published a landmark textbook on endocrinology called Innere Sekretion (Internal Secretions), which was a thorough study on glands and their secretions. In 1922, he described his studies of two sisters who had retinitis pigmentosa, polydactyly, hypogonadism as well as obesity.
  • Two years earlier Georges Bardet (1885–1966) at the University of Paris described the same symptoms in two sisters unrelated to Biedl's findings.
  • This syndrome is now called the Bardet-Biedl syndrome after the two men. A similar disease was originally named the "Laurence-Moon-Bardet-Biedl syndrome", together with two English physicians, John Zachariah Laurence (1829–1870) and Robert Charles Moon (1845–1914).
  • Today this disease has been shortened to become the Laurence-Moon syndrome, while the Bardet-Biedl syndrome is recognized as a separate entity. In 1928 he founded the journal Endokrinologie.

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