Marcantonio II Colonna (sometimes spelled Marc'Antonio; 1535 – August 1, 1584), Duke of Tagliacozzo and Duke and Prince of Paliano, was an Italian aristocrat who served as a Viceroy of Sicily in the service of the Spanish Crown, Spanish general, and Captain General of the Church.
He is best remembered for his part as the admiral of the Papal fleet in the Battle of Lepanto.