Otto Knefler (5 September 1923 – 30 October 1986) was a German association football player and manager.
As player he won the championship of the German Democratic Republic of 1952 with Turbine Halle, today known as Hallescher FC.
Between 1963 until his retirement in December 1973 he coached in the German Bundesliga and second division.
Major successes were the promotions to the Bundesliga attained with Eintracht Braunschweig and Borussia Dortmund, albeit with the latter he was dismissed before the end of the season.
Notably they were placed fourth in the Bundesliga with Braunschweig in 1971 and placed sixth with MSV Duisburg in 1978, which was the second-best placing ever for the club.