Santiago González Portillo (25 July 1818 – 1 August 1887) was a general from El Salvador.
He served as President of El Salvador from 15 April 1871 to 1 February 1876, and as Vice President and commander-in-chief of the army during the term of his successor, Andrés del Valle.He served as the minister of war of El Salvador from 1863 to April 1871.
He led a revolution in 1871 in which the conservative government was overthrown, and he amended the constitution.