Thokozani Khuphe (born 18 November 1963) is a Zimbabwean politician, trade unionist and the President of the MDC-T breakaway faction of the Movement for Democratic Change (MDC).
She was Deputy Prime Minister 2009-13.
Following the death of party founder Morgan Tsvangirai in early 2018 Khupe opposed the ascent of Nelson Chamisa as leader of the MDC-T on the grounds that she was the only one of its three Vice Presidents elected by congress, whereas Chamisa and the third vice president Elias Mudzuri had been appointed by Tsvangirai.
Khuphe was supported by much of the party organization in this, but lost the power struggle to Chamisa; Khuphe and her supporters consider their faction the legitimate MDC-T and have continued to use the MDC-T name.
They are involved in a court battle with the Chamisa faction over the party name, symbols, logo and trademark; the matter had not been resolved prior to the 2018 general elections and the Khuphe faction ran in the elections as the MDC-T while the much bigger Chamisa faction ran as part of the MDC Alliance.
On 22 April 2018, she was elected unopposed as the President of her MDC-T faction at an extraordinary congress in Bulawayo.